Methenolone Acetate

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Chemical Information and Compositions of Methenolone Acetate

For researchers, biochemists, and wholesale distributors, the molecular structure of methenolone acetate is a classic example of targeted structural modification to maximize anabolic selectivity and oral bioavailability.

Official Chemical Nomenclature

  • IUPAC Name: (5α,17β)-1-Methyl-3-oxoandrost-1-en-17-yl acetate
  • Chemical Formula: C22H32O3
  • Molecular Weight: 344.49 g/mol
  • CAS Number: 434-05-0

Structural Composition Breakdown

methenolone acetate is a synthetic derivative of Dihydrotestosterone (DHT). Its structural architecture features three vital modifications that define its pharmacological behavior:

  1. The 1-Methyl Group: This is the most crucial modification. By adding a methyl group at the C1 position, the molecule becomes highly resistant to the 3α-HSD enzyme. This allows methenolone acetate to reach the androgen receptors in skeletal muscle intact, where it can exert potent anabolic signaling. Additionally, this 1-methyl group drastically reduces the molecule’s intrinsic androgenic activity, shifting its profile heavily toward anabolism.
  2. 17-Alpha Alkylation (Indirect via Acetate): Unlike Dianabol or Anadrol, which use a 17-alpha-methyl group to survive oral ingestion (which is highly liver-toxic), methenolone acetate utilizes an acetate ester at the 17-beta position. While 17-alpha-alkylation is absent, the 1-methyl group provides some protection against first-pass hepatic degradation. However, the acetate ester is primarily responsible for its oral delivery, allowing the molecule to be absorbed through the lymphatic system and bypassing some of the immediate destructive liver metabolism. This structural choice makes methenolone acetate the least hepatotoxic oral steroid commercially available.
  3. 5-Alpha Reduced Structure: Because it is a DHT derivative, methenolone acetate is already 5-alpha reduced. It cannot be converted by the 5-alpha reductase enzyme into a more potent androgen. It binds to the androgen receptor in its inherent state.

Physical and Chemical Properties

  • State at Room Temperature: Solid (Crystalline Powder)
  • Color: White to off-white
  • Solubility: Practically insoluble in water; freely soluble in organic solvents such as chloroform, DMSO, ethyl oleate, and ethanol.
  • Melting Point: Approximately 138°C to 142°C.

Pharmacokinetics

  • Route of Administration: Oral
  • Half-Life: The biological half-life of methenolone acetate is approximately 2 hours. This is extremely short for an oral steroid. Because of this, the drug clears the system very rapidly, necessitating multiple daily doses (usually 2 to 3 times per day) to maintain stable androgen receptor saturation and stable blood plasma levels.
  • Anabolic/Androgenic Ratio: methenolone acetate possesses an anabolic rating of 88 and an androgenic rating of 44 to 57 (relative to methyltestosterone). While its raw anabolic rating is lower than steroids like Dianabol (90-210) or Trenbolone (500), its clinical effectiveness is profound because almost 100% of its activity results in lean tissue accretion without water or fat gain.
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